Interfacial Cholesterol Binding Sites on GPCRs
GPCRs Class C
[With residue numbers in the Pin numbering system; Units of E, kcals/mol with molar concentration units]
| PDB | E | Local Residues |
| Metabotropic glutamate receptor (mGlu) | ||
| Metabotropic glutamate receptor mGlu1, inactive, dimer with cholesterol, Human 4or2 | ||
| 4or2_EC | -13.5 | L608.A[1.55], F639.A[2.47], W588.B, S589.B, I594.B[1.41], I597.B[1.44], A598.B[1.45], C601.B[1.48], L605.B[1.52] |
| -13.3 | W588.A, S589.A, I594.A[1.41], I597.A[1.44], A598.A[1.45], C601.A[1.48], L605.A[1.52], L608.B[1.55], F639.B[2.47] | |
| -13.3 | L605.A[1.52], L608.B[1.55], F639.B[2.47], V643.B[2.51], F646.B[2.54], T647.B[2.55], T653.B, T655.B[3.27], S656.B[3.28], L659.B[3.31] | |
| -13.1 | T793.B[6.45], I796.B[6.48], I797.B[6.49], A800.B[6.52], I804.B[6.56], Y810.B[7.27], I813.B[7.30], T814.B[7.31], F817.B[7.34], L821.B[7.38] | |
| -13.0 | W588.A, I597.A[1.44], C601.A[1.48], L605.A[1.52], F646.A[2.54], I604.B[1.51], L608.B[1.55], F639.B[2.47], F646.B[2.54] | |
| -13.0 | T793.A[6.45], I796.A[6.48], I797.A[6.49], A800.A[6.52], I804.A[6.56], Y810.A[7.27], I813.A[7.30], T814.A[7.31], F817.A[7.34], L821.A[7.38] | |
| -13.9 | W588.A, F639.A[2.47], L640.A[2.48], V643.A[2.51], F646.A[2.54], T647.A[2.55], A650.A, L659.A[3.31], L663.A[3.35] | |
| -12.4 | L713.A[4.39], V716.A[4.42], L720.A[4.46], L751.A[5.38], V754.A[5.41], A755.A[5.42], G758.A[5.45], Y759.A[5.46], L762.A[5.49] | |
| 4or2_IC | -14.6 | V676.B[3.48], N680.B[3.52], R684.B[3.56], I709.B[4.35], L713.B[4.39], V716.B[4.42], Y759.B[5.46], L762.B[5.49], L763.B[5.50], S766.B[5.53], Y770.B[5.57] |
| -13.1 | F599.A[1.46], F789.A[6.41], F817.A[7.34], L821.A[7.38], T824.A[7.41], V825.A[7.42], G828.A[7.45], C829.A[7.46], T832.A[7.49] | |
| -12.7 | Y786.B[6.38], T793.B[6.45], L821.B[7.38], V825.B[7.42], G828.B[7.45], C829.B[7.46], T832.B[7.49], P833.B[7.50] | |
| -12.3 | E629.A[2.37], Y632.A[2.40], I633.A[2.41], A636.A[2.44], L640.A[2.48], L662.A[3.34], L663.A[3.35], L666.A[3.38], M670.A[3.42], W704.A[4.30], V707.A[4.33] | |
| -13.1 | T611.A[1.58], V615.A[1.62], Y632.A[2.40], A636.A[2.44], F639.A[2.47], L640.A[2.48], V643.A[2.51], L663.A[3.35] | |
| -12.7 | V676.A[3.48], N680.A[3.52], R684.A[3.56], I709.A[4.35], L713.A[4.39], V716.A[4.42], Y759.A[5.46], L762.A[5.49] | |
| -12.7 | F599.B[1.46], L602.B[1.49], V606.B[1.53], F609.B[1.56], T824.B[7.41], L827.B[7.44], G828.B[7.45], T832.B[7.49], M835.B[7.52], Y836.B[7.53], I839.B[7.56] | |
| -13.4 | L608.A[1.55], T611.A[1.58], L612.A[1.59], V615.A[1.62], F639.A[2.47], V643.A[2.51], L605.B[1.52], F609.B[1.56] | |
| -12.3 | W704.B[4.30], V707.B[4.33], I708.B[4.34], S711.B[4.37], I712.B[4.38], S715.B[4.41], L718.B[4.44], T719.B[4.45], V722.B[4.48] | |
| Metabotropic glutamate receptor mGlu1, inactive, Human 4oo9 | ||
| 4oo9_EC | -12.3 | L573, P578[1.38], I581[1.41], A582[1.42], V585[1.45], F586[1.46], L589[1.49], T811[7.41] |
| -12.1 | T780[6.45], I783[6.48], I784[6.49], I791[6.56], Y797[7.27], T801[7.31], F804[7.34], L808[7.38] | |
| -12.0 | I699[4.38], C702[4.41], I703[4.42], G706[4.45], V709[4.48], A710[4.49], I713[4.52], M714[4.53] | |
| -11.7 | I703[4.42], I707[4.46], L711[4.50], M714[4.53], L738[5.38], A742[5.42], Y746[5.46], L749[5.49] | |
| 4oo9_IC | -13.0 | V663[3.48], T664[3.49], Y667[3.52], I696[4.35], L700[4.39], Y746[5.46], L749[5.49], L750[5.50] |
| -12.5 | F586[1.46], L589[1.49], A593[1.53], F596[1.56], V819[7.49], V822[7.52], Y823[7.53], L826[7.56] | |
| -12.5 | E616[2.37], Y619[2.40], I620[2.41], A623[2.44], L627[2.48], L653[3.38], M657[3.42], L694[4.33] | |
| -13.1 | F586[1.46], Y773[6.38], L808[7.38], T811[7.41], V812[7.42], G815[7.45], C816[7.46], V819[7.49], P820[7.50] | |